Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder
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چکیده
منابع مشابه
Genetic Variants Involved in Bipolar Disorder, a Rough Road Ahead
Background Bipolar Disorder (BD), along with depression and schizophrenia, is one of the most serious mental illnesses, and one of the top 20 causes of severe impairment in everyday life. Recent molecular studies, using both traditional approaches and new procedures such as Whole-Genome Sequencing (WGS), have suggested that genetic factors could significantly contribute to the development of BD...
متن کاملCombinations of genetic variants associated with bipolar disorder
The main objective of the study was to find genetic variants that in combination are significantly associated with bipolar disorder. In previous studies of bipolar disorder, combinations of three and four single nucleotide polymorphisms (SNP) genotypes taken from 803 SNPs were analyzed, and five clusters of combinations were found to be significantly associated with bipolar disorder. In the pre...
متن کاملPropensity score based data analysis
For some time, propensity score (PS) based methods have been frequently applied in the analysis of observational and registry data. The PS is the conditional probability of a certain treatment given patient’s covariates. PS methods are used to eliminate imbalances in baseline covariate distributions between treatment groups and permit to estimate marginal effects. The package nonrandom is a too...
متن کاملIdentifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall's Tau.
Identifying replicable genetic variants for addiction has been extremely challenging. Besides the common difficulties with genome-wide association studies (GWAS), environmental factors are known to be critical to addiction, and comorbidity is widely observed. Despite the importance of environmental factors and comorbidity for addiction study, few GWAS analyses adequately considered them due to ...
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BACKGROUND Mitochondria provide most of the energy for brain cells by the process of oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative phosphorylation have been reported in individuals with schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) in transcriptomic, proteomic, and metabolomic studies. Several mutations in mitochondrial DNA...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2011
ISSN: 0741-0395
DOI: 10.1002/gepi.20558